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{% if content.field_example|render|striptags|trim %}
  <p>field is not empty</p>
{% endif %}

<table class="highlighttable"><tr><td class="linenos"><div class="linenodiv"><pre><a href="#L-1">1</a> <a href="#L-2">2</a> <a href="#L-3">3</a></pre></div></td><td class="code"><div class="highlight"><pre><span></span><span id="L-1"><a name="L-1"></a>{% if content.field_example|render|striptags|trim %} </span><span id="L-2"><a name="L-2"></a> &lt;p&gt;field is not empty&lt;/p&gt; </span><span id="L-3"><a name="L-3"></a>{% endif %} </span></pre></div> </td></tr></table>